簡(jiǎn)要描述:英文名稱(chēng): CHIR99021產(chǎn)品應(yīng)用: WNT信號(hào)通路調(diào)控中國(guó)俗稱(chēng): CHIR99021 注冊(cè)品牌: StemRD 生產(chǎn)廠家: 美國(guó)StemRD公司訂購(gòu)貨號(hào): CHIR-50規(guī)格型號(hào): 50mg保存溫度: ﹣20℃產(chǎn)品種類(lèi): 小分子工具到貨時(shí)間: 1~5天
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產(chǎn)品英文名稱(chēng): CHIR99021
產(chǎn)品中文名稱(chēng): CHIR99021
訂購(gòu):
CHIR99021產(chǎn)品英文簡(jiǎn)述:
CHIR99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor with IC50 less than 10 nM. Compared to other GSK-3 inhibitors, CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) with 350-fold selectivity toward GSK-3β compared to CDKs .
Ref: Tighe A et al. BMC Cell Biol. 2007 Aug 14;8:34
Purity: Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 50 nM.
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